TECHNOLOGY

Zonula's small molecules inhibiting fibroblast adhesion represent a new approach to treating rheumatoid arthritis (RA).

Cell adhesion, the process by which cells stick to one another, is a fundamental biological property. Zonula's small molecules bind to cell surface glycoproteins, known as cadherins (biological glues) and prevent cell adhesion (see diagram below). These molecules control fibroblast adhesion, activity and survival in bone joints.

Inflammation occurring during RA causes fibroblasts in bone joints to proliferate and erode the cartilage. Zonula's small molecule cadherin inhibitors stop the fibroblasts from proliferating and decrease their ability to degrade cartilage.